Services

Manufacturing
Solutions

The foundation of our business is “The Hearth”, a 175,000 ft2 custom-designed, cGMP facility, dedicated to AAV viral vector manufacturing. We offer end-to-end manufacturing and development services to accelerate gene therapy programs from preclinical stage through clinical, and on to commercial manufacturing.

Proprietary IgnitionTM Cells
  • HEK293 serum free suspension system
  • Open Licensing and royalty-free usage
  • Developed for yield and consistency
Research and Development Capabilities
  • Experienced team able to support process development and scale up
  • End-to-end capabilities from research to GMP grade, reducing the need for bridging studies
  • 1L-50L research and toxicology grade production available Q3 2020
GMP Manufacturing
  • Fully disposable, closed system processing
  • 50L-500L GMP grade production in 2021
  • Flexible scheduling and maximization of capacity
  • Consistent process and product flow for reduction of variation
Facility
  • Building a state of the art, custom 175,000 ft2 office and production facility
  • cGMP compliant facility designed for EU/US use
Services

Blaze Vector™ Production

Blaze Vector™ Production

“There is a shortage of high-quality AAV research scale production in a time-efficient manner – and we are here to help. We want to be your partner from Blaze Vector Production through cGMP manufacturing, which is why we are focused on quality from the start.“

- David Dismuke, Ph.D., Chief Technical Officer

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The details

Forge provides scalable, premier research-grade AAV production that allows companies to go from research to cGMP with consistent processes. Blaze Vector Production provides a higher purity vector using chromatography-based purification combined with a suite of robust release assays. Blaze Vector Production is core to our mission of enabling access to life-changing discoveries by bringing them from concept to reality.

What we bring to the table

  • Our proprietary Ignition™ cells will help you go from concept to clinic. Our Ignition™ cells are serum-free HEK293s optimized for yield and consistency in suspension system and we offer open licensing and royalty-free usage.
  • Established process for many standard AAV serotypes
  • Process development to perform experiments on novel engineered capsids
  • Experienced team with decades of AAV manufacturing experience
  • At Forge we are focused on upfront communication and pricing to help ensure your needs are met
  • 1:1 client support
  • Fast turnaround time

Small Scale - 1 L

30-50L Toxicology Production is also available.

We’d love to begin building a relationship and learn how we can best serve you - simply complete the form below.

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