Innovative AAV Manufacturing Platform

FUEL™

As gene therapy developers push the boundaries of innovation, manufacturing must keep pace. Forge’s FUEL™ platform delivers a more efficient manufacturing foundation — with advanced technologies, proven processes, and product-specific optimizations to propel your program forward.

fuel your program

advanced technology

pEMBR™ 2.0 Ad Helper

As one of the smallest Ad helpers commercially available at 8.9 kb, pEMBR™ 2.0 increases manufacturing efficiency, offers an improved safety profile by reducing unnecessary adenoviral components for AAV production, and is Forge-specific intellectual property.

The Science Behind pEMBR 2.0

advanced technology

Modified Rep/Caps

Designed for safety and higher AAV yields, Forge’s patent pending modified rep/cap incorporates the client-specific capsid sequence into its proprietary backbone plasmid.

advanced technology

Ignition Cells™

Our suspension HEK293 Ignition Cells™ are optimized for robust transient transfection and can achieve over 90% full capsids post-enrichment, often with undetectable particles. Ignition™ Cells are supported by fully qualified Master Cell Bank and Working Cell Bank.

Novel Capsid? Yeah, Our Platform Can Work With That.

The FUEL™ platform is designed to support all serotypes, including novel capsids.

Lets fuel progress

Higher Yield, Better Recovery, Same Unmatched Quality

Explore how FUEL™ boosts productivity, scales seamlessly, improves recovery, and maintains consistent quality.

productivity

The FUEL™ platform and product-specific optimizations can increase productivity 6-22x.

scalability

FUEL™ offers seamless transitions across development stages, providing developers with reliable and scalable production.

quality & recovery

The FUEL™ platform provides increased recovery and consistent quality attributes.

Product-Specific Optimizations

FUEL™ offers a strong foundation for further enhancements, combining platform technologies with product-specific optimizations to help you achieve high yield, consistent quality, and reliable performance. Here are some of the optimizations we’ve used to help developers achieve their goals.

Yield Optimization

Downstream Scalability

Downstream Recovery

Ready to FUEL your program?

Ready to Fuel Your Program?

Let’s talk about how we can help accelerate your therapy to patients.

fuel up

Frequently Asked Questions

Does Forge Biologics provide AAV CRO services?

Forge Biologics is a CDMO (Contract Development and Manufacturing Organization) and does not provide CRO services. We specialize in AAV manufacturing, offering research-grade production, process development, GMP manufacturing, and integrated support services such as molecular development, analytics, and regulatory consultation. While we don’t provide traditional CRO services—like preclinical or clinical trial management—we work closely with clients to support their manufacturing strategy throughout the development lifecycle and maintain preferred partnerships with CROs that we can connect our clients to as needed.

How quickly can Forge deliver a GMP batch?

Timelines for GMP batch delivery are highly dependent on the specifics of your program, including vector design, process readiness, and scope of work. By partnering with Forge and leveraging our proprietary platform and integrated services—such as in-house analytics and plasmid production—developers may accelerate timelines to GMP manufacturing by up to 30% compared to full process development. Connect with our Client Development team to discuss your program and receive a more detailed scope of work based on your program needs.

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