The Hearth
The Hearth is Forge’s 200,000+ sq. ft. cGMP facility where your discovery scales. With 20 cGMP suites and bioreactors ranging from 50 to 5,000L, it’s one of the largest manufacturing sites in the world dedicated to AAV, giving you the scale, compliance, and confidence to advance your therapy.
Fueling Big Ideas with Bold Scale
Designed with the details you care about and the scale you need, our cGMP facility combines advanced systems, rigorous compliance, and flexible infrastructure to help bring your program to life. We’re obsessed with getting every element right—here’s a glimpse into the facility built for you.
20+ Custom cgmp suites
More Suites, More Capacity for You
Our 20 custom-designed cGMP suites are built to optimize throughput and support seamless scale-up and scale-down. The facility is also designed for future expansion, with space for additional suites.
1-5,000l bioreactors
Scaling Up for More Programs and Larger Indications
Our cGMP suites offer a variety of bioreactor types and scales ranging from 50-5,000L. Our scales include research-grade (1–40L), process development (1–1,000L), toxicology (50–1,000L), and engineering and cGMP manufacturing (50–5,000L).
rigorous Quality unit
30% of Our Team Focused on Quality for You
Our Quality organization, representing 30% of our team, is divided into two key functions: Quality Management, which includes Quality Assurance, Quality Systems, Quality Engineering, Validation, and Supplier Quality Management; and Quality Control, which covers Analytical, Microbiology, Environmental Monitoring, and Raw Materials and Inspection.
reach
Built for All
Forge has solutions for all gene therapy innovators.
Any stage. Any scale. Built around your journey.
Researchers
Partner with Forge to advance your therapy from concept to clinical success with tailored support.
Foundations
Our mission is to support foundations in creating innovative therapies that changes lives for the better.
Biotechs
Unlock your biotech potential with our tailored support for every stage of your journey.
Pharmaceutical Companies
We have the capacity to meet your needs today and scale for tomorrow’s challenges.
Forged in
Columbus, Ohio
Rooted in a region with a strong legacy in gene therapy innovation, Forge is growing in a community defined by top talent, strong partnership, and continued investment. Discover why we’re building something special here.
See Your Path Forward
A Story of Partnership
A prominent feature of our manufacturing facility is a mural that symbolizes our partnership with clients, reflecting how we work alongside them from concept to therapy and the trust, collaboration, and shared commitment it takes to bring treatments to patients.
The foundry
Built for Collaboration
At the heart of our facility is the Foundry is where innovation and purpose come to life. It’s a space where teams unite to solve complex challenges, celebrate big wins, and share powerful stories, from technical advancements to patient voices, all in pursuit of our steadfast mission.
Explore the Infrastructure Designed for Your Journey
See how our purpose-built facility supports every stage of your program, from early development through cGMP manufacturing, with the onsite analytics and quality needed to move forward with confidence.